Evidence suggests that COLCRYS may decrease the pain of gout flares by interfering with the action of
certain inflammatory cells
The primary cause of gout is having too much uric acid in the blood. This condition, known as "hyperuricemia,"
may cause needle-like crystals to be deposited in joints. Scientific evidence suggests that the immune system
reacts to this buildup of uric acid crystals by activating certain inflammatory cells, causing the pain and
inflammation associated with a gout flare.
COLCRYS does not treat high uric acid levels (the cause of gout), and has not been shown to prevent joint deformities and tissue destruction.
Uric acid buildup in joints
Gout flares can also occur when someone starts taking a uric acid-lowering medicine. As these medicines start
working, they can cause crystal deposits in the joints to begin breaking apart. The immune system responds to
these moving crystals by causing pain and inflammation.
How can COLCRYS help?
Evidence suggests COLCRYS may prevent these immune responses, which can help reduce gout flare pain.
While the effect of colchicine (the main ingredient in COLCRYS) described here has been studied,
it isn't known exactly how colchicine works to treat gout flare pain.